alexa Biapenem For Treatment Of Diabetic Foot Infection: A Case Series | 69871
ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
Open Access

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3rd World Congress and Exhibition on Antibiotics and Antibiotic Resistance

Chumpon Wilasrusmee
Mahidol University, Thailand
Posters & Accepted Abstracts: J Drug Metab Toxicol
DOI: 10.4172/2157-7609-C1-009
Abstract
Introduction: Biapenem is a parenteral carbapenem antibiotic that has powerful antibacterial activity. The aim of this study is to evaluate the efficacy and safety of biapenem for the treatment of diabetic foot infection. Findings: A total of 200 patients presenting to tertiary care medical centers with severe diabetic foot infection and suspected diagnosis of osteomyelitis and biapenem use from 01/2014 to 02/2015 were screened, and 20 patients met inclusion criteria for this study. Mean age was 56.25±12.47 years, 40% were male, 85% were Central Asian Arabic, and the most common comorbidities included, peripheral vascular disease (82%), hypertension (74%), dyslipidemia (82%) and history of tobacco use (55%). Over half of the patients presented to out-patient clinic or emergency room more than six months after the onset of symptoms. Bone culture was obtained for diagnostic guidance in 8 cases; and surgical intervention was performed in 18 cases. Patients received a mean duration of 19.8±12.23 days of therapy, and in 80% of cases, subsequent oral antibiotics were used. Three cases were treated as out-patient. 16 (80%) patients met criteria for clinical success, defined as resolution of clinical signs and symptoms of infection such that wound healing and discontinuation of antibiotics. The treatment was seemed appropriate at end of biapenem therapy, without recurrence at one year follow-up. No adverse drug effects were noted. Conclusions: In this case series of mostly severe, lower extremity diabetic foot infection, an average 20 days course of empiric biapenem was well-tolerated with curative rates of 80% at one year and three cases were treated as out-patient.
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