alexa Bioactive Chemical Compositions And In Vitro Assessments Of Antioxidant And Antidiabetic Potentials Of Ethanol Extract Fractions From Ehretia Cymosa Thonn
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
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5th International Conference and Exhibition on Pharmacology and Ethnopharmacology
March 23-25, 2017 Orlando, USA

Akintayo L Ogundajo and Anofi O T Ashafa
University of the Free State, South Africa
Posters & Accepted Abstracts: Clin Exp Pharmacol
DOI: 10.4172/2161-1459.C1.017
Abstract
Ehretia cymosa Thonn is a popular medicinal plant used in different parts of West Africa for the treatment of various ailments including diabetes mellitus. The current study investigates bioactive constituents and in vitro antioxidants and antidiabetics potentials of ethanol extract fractions from E. cymosa. Phytochemical investigation and antioxidant assays were carried out using standard procedures, antidiabetic potential was assessed by evaluating the inhibitory effects of the extract fractions on the activities of α-amylase and α-glucosidase while bioactive constituent’s identification was carried using GC-MS analysis. The phytochemistry tests of the extract fractions revealed the presence of tannins, phenols, flavonoids, steroids, terpene, alkaloid and cardiac glycosides. Methanol fraction showed higher phenolic (27.44 mg gallic acid g-1) and flavonoid (235.31 mg quercetin g-1) contents while ethylacetate fraction revealed higher proanthocyanidins (28.31 mg catechin g-1). Methanol fraction displayed higher (p<0.05) DPPH (0.47 mg/mL), ABTS (0.49 mg/mL) and hydroxyl radical (0.55 mg/mL) scavenging activities while ethylacetate exhibited strong metal chelating (0.61 mg/mL) and superoxide anion (1.68 mg/mL) scavenging activity. Methanol and ethylacetate fractions displayed higher inhibition (p<0.05) against α-glucosidase (0.60 mg/mL) and α-amylase (2.11 mg/mL), respectively. Methanol fraction also inhibited α-amylase and α-glucosidase in competitive and non-competitive modes, respectively. The GC-MS chromatogram of the methanol fraction revealed 24 compounds which include phytol (1.78%), stearic acid (1.02%) and 2-hexadecyloxirane (34.18%) which are known antidiabetic and antioxidant agents. The results indicate E. cymosa leaves as source of active phytochemicals with therapeutic potentials in the management of diabetes.
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