alexa Bioanalytical Method Development And Validation Of Metaxalone In Human Plasma By LC-MS/MS | 64406
ISSN: 2167-1079

Primary Healthcare: Open Access
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3rd Annual Congress & Medicare Expo on Primary Healthcare, Clinical & Medical Case Reports
April 17-19, 2017 Dubai, UAE

Nirav R Soni
A-ONE Pharmacy College, India
Posters & Accepted Abstracts: Primary Health Care
DOI: 10.4172/2167-1079-C1-006
Abstract
A simple, rapid, sensitive, and selective liquid chromatography-tandem mass spectrometry (MS) method was developed and validated for the quantification of Metaxalone, a skeletal muscle relaxant, in human plasma using Metaxalone –D6 as internal standard (IS). Following Liquid-Liquid Extraction (LLE), the analytes were separated using an isocratic mobile phase on a reverse phase C18 column (Chromatopak peerless basic 50× 4.6 mm× 3.0 μm ) and analyzed by MS in the multiple reaction monitoring mode using the respective [M+H]+ ions, m/z 222.14/ 160.98 for Metaxalone and m/z 228.25 /167.02 for the IS. The assay exhibited a linear dynamic range of 25.19-2521.313 ng/mL for Metaxalone in human plasma. The goodness of fit was consistently greater than 0.98 during the course of validation. The range of accuracy and precision of the back-calculated concentrations of the standard curve points was from 94.1 % to 104.4 % and 0.3 % to 5.6 % for Metaxalone. A run time of 2.0 min for each sample and injection volume is 5 μl. The validated method has been successfully used to analyze human plasma samples for application in pharmacokinetic, bioavailability, or bioequivalence studies.
Biography

Nirav R Soni has completed his MPharm from Gujarat Technological University (GTU) and he has taken Postgraduate Diploma Intellectual Property Rights (PGDIPR). He got “Best Teaching Award” and he has achieved award of “Best-Student of the year” for the year 2013. Recently, he got "National Award"- PEARL Foundation, “Best Assistant Professor Award in Pharmacy” for the year 2016. Also, the “International Young Leadership Awards-2016” - TIME Cyber Media Pvt. Ltd., and the “Best Upcoming Young Researcher in Ahmedabad” for the year 2016. He cracked GPAT (Graduate Pharmacy Aptitude Test-2013, AICTE) and got stipend from the Indian government. He has research experience in the Bioanalytical department and published thesis. Also, he has published books with ISBN. He has published research, review articles and letter to the Editors in reputed international journals. He has been serving as an Editorial Board Member as well as reviewers of reputes.

Email: [email protected]

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