Reach Us +1-217-403-9671
Bioavailability Study Of Zolmitriptan Sublingual Tablets On Sheep Model | 8239
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Bioavailability study of zolmitriptan sublingual tablets on sheep model

2nd World Congress on Bioavailability & Bioequivalence: Pharmaceutical R & D Summit-2011 and International Conference on Pharmaceutics & Novel Drug Delivery Systems

Ziya BAYRAK, Cetin TAS, Umut TASDEMIR, Halil EROL, Cansel KOSE OZKAN, Ayhan SAVASER and Yalcin OZKAN

ScientificTracks Abstracts: JBB

DOI: 10.4172/2153-2435.10000S4

S ublingual tablet administration has an important fi eld in therapy because of taking immediate pharmacologic response, bypass of fi rst pass eff ect and so high bioavailability and patient satisfaction. Zolmitriptan is a good candidate as an active pharmaceutical ingredient in sublingual tablet formulations because of its freely soluble in water, exposing fi rst pass eff ect and high potency impact. Sublingual tablet formulations were prepared with diff erent polymers such as hydroxypropyl methyl cellulose (HPMC), chitosan and sodium carboxy methyl cellulose (CMCNa) with direct compression method. Th e eff ect of polymers has been investigated on in vitro and in vivo drug studies. In vitro studies show that all formulations met the pharmacopeial criteria. Th e optimum formulations for diff erent ratios of polymers were chosen for in vivo bioavailability studies on sheep model. A simple solution formulation of zolmitriptan was used for in vivo studies to calculate relative bioavailability of sublingual tablets. Th e results of in vivo studies showed that formulation containing 5% chitosan, has the maximum C max and AUC and minimum t max values (p < 0.05). Increasing the contact time with the sublingual mucosa with a mucoadhesive polymer improve sublingual bioavailability and result in more predictable plasma levels of the drug, leading to better therapeutic effi cacy. As a result sublingual tablet administration of zolmitriptan formulated with appropriate excipients and especially with chitosan seems promising alternative to traditional routes
Ziya Bayrak has begun doctoral studies in 2009. He continues doctorate education in Gulhane Military Medical Academy, Department of Pharmaceutical Technology. The main fi elds of research area are tablets, drug absorption and penetration from mucosa and skin