alexa Biochemical And Histological Study On Effect Of Bone Marrow Derived Cells In Treatment Of Cardiomyopathy In Adult Diabetic Albino Rat | 64899
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
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7th World Hematologists Congress

Eman AbdelHay Ahmed Mashhour
Tanta University, Egypt
Posters & Accepted Abstracts: J Blood Disord Transfus
DOI: 10.4172/2155-9864-C1-023
Abstract
Diabetic cardiomyopathy (DCM) is a clinical condition, diagnosed when ventricular dysfunction develops in patients with diabetes mellitus (DM) in the absence of coronary artery disease, valvular heart disease or hypertension. 75% of patients with unexplained idiopathic dilated cardiomyopathy were found to be diabetic. Stem cells are capable of self-renewal through replication and differentiation into specific lineages aiding in tissue repair, they have a unique capacity to produce unaltered daughter cells (selfrenewal) and to generate specialized cell type (potency). Chronic hyperglycemia is responsible for myocardial remodeling and is a central feature in the progression of DCM, which is characterized by hypertrophy and apoptosis of cardiomyocytes. Microcirculatory defects, necrosis and interstitial fibrosis are the main pathological characteristics of DCM. MSCs can induce myogenesis and angiogenesis either by releasing different angiogenic, mitogenic and antiapoptotic factors or by differentiating into cardiomyocytes. The aim of the current study is to evaluate the beneficial effect of transplantation of isolated, expanded and cultured bone marrowderived cells from rat as treatment of experimentally induced diabetic cardiomyopathy in other adult albino rat.
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