alexa Biochemical Approaches For Diabetic Management
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

14th International Conference and Exhibition on Targeting Diabetes and Novel Therapeutics
October 17-18, 2016 Kuala Lumpur, Malaysia

Khalid Mohammed Khan
University of Karachi, Pakistan
Posters & Accepted Abstracts: J Diabetes Metab
DOI: 10.4172/2155-6156.C1.058
Diabetes mellitus is the most prevalent metabolic syndrome world-wide, characterized by hyperglycemia (increase in glucose level) resulting in various short-term metabolic changes in lipid and protein metabolism and long-term irreversible vascular changes. When proteins are exposed to elevated levels of glucose a series of non-enzymatic chemical reactions occur that lead to the gradual buildup of advanced glycation end products (AGEs) in body tissues that cause various complications in the body. Hyperglycemia, affects eyes (cataract), blood vessels (atherosclerosis), nerves (neuropathy), kidney (nephropathy) and cause impaired wound healing. Postprandial hyperglycemia is an independent risk factor for cardiovascular diseases. Non-enzymatic models for anti-glycation i.e., BSA-MG and enzymatic model α-glucosidase inhibition will be discussed. In glycation, reactive intermediate methyl glyoxal (MG) binds with amino acid more easily than its carbohydrate precursor. Serum albumin, 80% of blood protein, is more prone to non-enzymatic glycation. Inhibition of protein glycation due to hyperglycemia is therefore an important and attractive approach towards the prevention and management of late diabetic complications. Alpha-glucosidase is an enzyme responsible for the conversion of complex carbohydrates to glucose. Keeping this in view, our group is working for investigation of novel anti-glycating agents. Based on virtual screening results, we have synthesized several classes of compounds and evaluated them for their in vitro and in vivo α-glucosidase inhibitory potential and methyl glyoxal binding potential. All these interesting results will be discussed in detail during talk.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version