This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
In this study, we developed biodegradable poly[(d,l)-lactide-co-glycolide] nanofibrous membranes via electrospinning that
provided a sustained release of BCNU. An elution method and a HPLC assay were employed to characterize the in-vitro
and in-vivo release behaviors of pharmaceuticals from the electrospun membranes. The experimental results show that the
biodegradable, nanofibrous membranes released high concentrations of BCNU for more than 6 weeks in the cerebral cavity
of rats. Furthermore, the membranes can better conform to the geometry of the brain tissue and can cover more completely
the tissue after the removal of tumors, achieving better drug transport without interfering with the normal function of the
brain. Histological examination showed no obvious inflammation reactions of the brain tissues. By adopting the electrospinning
technique, we will be able to manufacture biodegradable, nanofibrous membranes for the long-term deliveries of various anti-
cancer drugs in the cerebral cavity, which can enhance the therapeutic efficacy of GBM treatment.
S.J. Liu earned his Master and Ph.D. degrees from Cornell University and the University of Wisconsin at Madison in 1989 and 199
2 respectively. Prof.
Liu had been working as a Post-doctoral research fellow at McMaster University of Canada, and also been as a visiting professor
to the Tokyo Institute of
Technology in Japan and Aachen University of Applied Science in Germany. Prof. Liu received the Morand Lambla Award from the International Polymer
Processing Society in 2008. He is the author of more than 200 scientific publications including 120 referred journal papers, editor and co-editor of 6 books
and the author of 15 patents. Prof. Liu is also serving as the Editor of
Journal of Polymer Engineering (SCI)
and the Associate Editor of
Asia Pacific Journal
of Chemical Engineering (SCI).
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals