alexa Biological Effects Of Dietary Plant Unsaturated Fatty Acids (UFAs)
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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5th International Conference on Medicinal Chemistry & Computer Aided Drug Designing and Drug Delivery
December 05-07, 2016 Phoenix, USA

Ashour Saleh Eljamil
Tripoli University, Libya
Posters & Accepted Abstracts: Med chem
DOI: 10.4172/2161-0444.C1.028
Abstract
Dietary UFAs plays considerable roles in human body particularly in modulating plasma cholesterol concentrations and determining the risk for coronary heart disease (CHD). UFAs are characterized by the presence of one or more double bonds, and they are classified as omega-3 (n-3) and omega-6 (n-6) based on the location of the last double bond relative to the terminal methyl end of the molecule. The significance of unsaturated fatty acids (UFA) in normal mammalian physiology was first established by Burr and Burr in 1929, who showed that linoleic acid (LA, C18:2n-6) and α-linolenic acid (ALA, C18:3n-3), are required for normal health and development but are not produced by the human body. Because they must be supplied by the diet, they are called essential fatty acids. LA and ALA are the simplest members of the most biologically significant polyunsaturated fatty acid (PUFA) families, called n-6 and n-3 PUFA respectively that regulate a wide variety of biological functions, which range from blood pressure and blood clotting to the correct development and functioning of the brain and the nervous system. Epidemiological evidence has been shown for the inclusion of n-9 monounsaturated fatty acids (MUFA) with n-6 and n-3 PUFA for replacement of dietary saturated fatty acids to provide added health benefits. The focus of the present paper is to review the dietary requirements, sources, and the biological effects of dietary plant n-9 MUFA, and n-6 PUFA on the human body.
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