Biological potent heteroaryl ketone Schiff base and thorium(IV) complexes of 2-benzoaminothiazole

8^th International Conference on Tissue Science and Regenerative Medicine

September 11- 12, 2017 Singapore

Neelima Mishra

Sanskriti University, India

Scientific Tracks Abstracts: J Tissue Sci Eng

Abstract :

Metal-based antioxidants has received effort in order to identify the compounds having high free radical scavenging capacity related to various disorders and diseases associated with oxidative damage due to reactive oxygen species (ROS). Two mononuclear Th(IV) complexes were derived from 2,3�dihydro�1H�indolo[2,3�b] phenazine�4(5H)�ylidene) benzothiazole�2�amine (L1) and 3�(ethoxymethylene)� (2,3�hihydro�1H�indolo [2,3�b] phenazine�4(5H)�ylidene) benzothiazole�2�amine (L2) with properties of pharmacologically interest. The compounds were characterized by elemental analyses, molar conductance, magnetic susceptibility measurements, FTIR, UV-Vis, 1H NMR, TGA and XRD studies. In both complexes 2:1 ligand-to-metal ratio has been observed. Ligands and metals complexes showed antimicrobials and antioxidants activities. Antioxidant property is shown by DPPH and H2O2 Scavenging methods. Antimicrobial activities against E. coli, S. aureus bacteria and C. tropicalis, A. niger by test tube method.

Biography :

Neelima Mishra has completed her PhD from Banasthali University, India. She is the Assistant Professor of Sanskriti University Mathura, India. She has published more than 15 papers in reputed journals, written two books and has been serving as an Editorial Board Member of national journal. Her research work mainly focuses on syntheses and biological potent of Schiff base metal complexes of La(III), Ce(III) and Th(IV) and syntheses of natural and synthetic polymers. She is the Member of India Science Congress, Chemical Teacher Association, Indian Chemical Society, Royal Society of Chemistry and American Chemical Society.