sed in conjunction with other technologies the light beam becomes
a uniquely powerful tool to study cells. We use this light source
not only to observe cells, but also to stimulate cellular chemistry. This
area of biophotonics is called ?caged compounds? as synthetic organic
chemistry is used to make biologically signaling molecules functionally
inert; irradiation liberates the caged molecules, thus ?switching on? a
chosen signaling pathway. We have developed many caged compounds
for stimulating both intracellular and extracellular receptors. With
reference to IP3-Calcium signaling cascade, here I describe few
examples of widely used caged compounds, their design features,
synthesis and some extent their applicability in living cells.
Fluorescent imaging probes are also playing vital role in recent years
and becoming a part In the process of drug discovery and development.
I also describe here on the development of imaging probes in reference
to the Alzheimer Disease (AD) for diagnosis and drug development.
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