Biosensor For Single Cell Entrapment And Study Of Cellular Pathways | 2719
Journal of Biosensors & Bioelectronics
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All aerobatic species on the earth uses O2 in its respiration. This metabolic process of respiration also produces reactive
oxygen species such as super oxides (O-2.), hydroxyls (OH.), peroxyl (LO2.), alcoxyl (LO.), hydroperoxyls (HO2.). Toxic
effects of these oxidative species can attack DNA, lipids, proteins and nucleic acids present in the body and may even lead to
cell death. Mammalian cell has many antioxidants to balance the side effects of these free radicals. When the imbalance between
antioxidants and reactive species becomes larger, indicates the pathological condition of body. Oxidative stress has been linked
to many diseased conditions in human, such as inflammation, heart disease, cancer, neuronal diseases, etc. 8-hydroxy 2-deoxy
guanine (8-OHDG) is the most frequently detected and studied oxidative DNA lesion. We propose to fabricate a lab on chip
device to study single cell exocytosis of 8-OHDG under stress conditions. We are also integrating two approaches to trap a single
cell by dielectrophoresis and surface modification. Dielectrophoresis allows us to capture a single cell in few seconds while
surface modification helps us avoid nonspecific adsorption and longer cell viability during our studies.
Pratikkumar Shah is pursuing his Ph.D at the Florida International University (FIU) in Biomedical Engineering major. His area of research interests
are biosensors, point of care devices and single cell studies. Mr Shah has finished his masters from New Jersey Institute of Technology (NJIT) with
an honor of 4.0/4.0 GPA in Biomedical Engineering major before joining FIU. He has been part of many hospitals and industrial corporations including
Siemens Hearing Instruments, NJ, USA during his academic and professional track record.
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