Reach Us +1-504-608-2390
Blockade Of CD40/CD40L Interactions Early In Life Abolishes Sj?gren?s-like Manifestations In Aged NOD.H2H4 Mice | 19616
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences

7th International Congress on Infectious Diseases

Berlin, Germany

4th International Conference on Mass Spectrometry

Milan, Italy
Share This Page

Blockade of CD40/CD40L interactions early in life abolishes Sj?gren?s-like manifestations in aged NOD.H2H4 mice

3rd International Conference and Exhibition on Clinical & Cellular Immunology

Tamer I Mahmoud and Rachel Ettinger

ScientificTracks Abstracts: J Clin Cell Immunol

DOI: 10.4172/2155-9899.S1.017

Primary Sj?gren?s syndrome (pSS) is an autoimmune disease that is characterized by autoantibodies (autoAbs). Longitudinal data demonstrate that pre-symptomatic autoAbs arise years to decades prior to the diagnosis of pSS. Understanding the underlying mechanisms and delineating if an early life window exists where autoAbs can be inhibited is critical for disease intervention. pSS is closely modeled in non-diabetic NOD.H2h4 mice where we detect autoAbs months before the neogenesis of salivary gland (SG) tertiary lymphoid structures and xerostomia. Importantly, shortly prior to the emergence of autoAbs, spontaneous splenic germinal centers (GC) appear early in life. To determine if SG ectopic follicles and autoAbs arise from spontaneous splenic GC early in life, GC?s were disrupted by a single administration of anti-CD40L mAb at 4 weeks of age. Blockade of CD40/CD40L interaction effectively disrupted splenic GC for over 2 months. Moreover, loss of GC in the spleen was followed by a dramatic loss of SG ectopic follicle development in aged mice. Notably, a single administration of anti- CD40L at 4 weeks of age significantly inhibited autoAb titers. However, no effect on autoAb was observed if a single dose of anti-CD40L was given at 5 weeks of age. Our findings highlight the contribution of immune dysregulation to the development of organ-specific autoimmune disease. Furthermore, these data demonstrate that early prophylactic intervention can inhibit auto Abs and ectopic lymphoid structures in an animal model of pSS.
Tamer I Mahmoud joined MedImmune as a postdoctoral fellow in 2012. Working with the Autoimmunity group he is characterizing the events that initiate or exacerbate chronic inflammation in the salivary glands of a mouse model of primary Sj?gren?s Syndrome. Tamer?s experience in autoimmunity is complemented by his long standing interest in studying the diversity of the B cell repertoire as well as cell subsets that respond to blood-borne pathogens. Tamer received his B.Sc. in Pharmaceutical Sciences from Cairo University. In 2009, he earned his PhD from the University of Alabama at Birmingham.