alexa Blocking Of Axl Receptor For Prevention Of Zika Virus Entry Into Neuroepithelial Cells Could Be A General Strategy Against Flavivirus Infection | 67179
ISSN: 2168-958X

Journal of Glycobiology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd Glycobiology World Congress

Edita Sarukhanyan and Thomas Dandekar
Julius-Maximilians University of W├╝rzburg, Germany
ScientificTracks Abstracts: J Glycobiol
DOI: 10.4172/2168-958X-C1-008
Abstract
Zika virus belongs to the family of Flaviviruses. It evoked a worldwide attention after a large outbreak in Brazil in 2014. New drugs against Zika virus and flaviviridae in general are highly desirable. It has been observed by researchers that the attachment of the flaviviruses to the host cell occurs in the case when the glycosylation of the asparagine in the envelope protein of the virus takes place. However, the viral proteins are quite sensitive and can easily undergo mutation. Therefore, the focus was switched to the host target. Following this idea we have found in the recently published literature that the Flavivirus internalization to the host cell is mediated by the Axl (one of the proteins from TAM family) receptor; in particular, when the dimerization of the last one with its ligand Gas6 takes place. Gas6 binds to the glycosylated protein in the envelope of the virus, hence, facilitating the attachment and entry of the virus into the host cell. Herein, we hypothesize that the blocking of a host-factor, the Axl receptor, could be a best way to block Zika virus infection cycle. Instead of directly targeting the virus, we suggest improved compounds targeting Axl-Gas6 interaction site by in silico modification of the known Axl blockers; an anticoagulant drug Warfarin and an anticancer drug R428. We have obtained better binding for both extending modifications, which was shown by docking simulation results.
Biography

Edita Sarukhanyan has obtained her Bachelor and Master of Science degrees in Physics (Biophysics) from Tbilisi State University in Georgia. In 2013, she has received PhD title in Chemistry (Computational Chemistry) from the Joint International PhD Program between University of Salerno in Italy and Jacobs University Bremen in Germany. Her thesis work was related to multiscale simulation studies of interactions of carbon nanotubes with biopolymers and lipid membranes. Since 2015, she is a Postdoctoral Researcher at the University of Würzburg in Germany. Her current research is mainly focused on in silico drug design and development.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7