alexa Blood Based Biomarkers For Diagnosis, Prognosis And Monitoring Of Patients With Melanoma
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

16th European Dermatology Congress
June 07-08, 2017 Milan, Italy

Mel Ziman, Pauline Zaenker, Michael Millward, Tarek Menaiwy, Adnan Khattak, Rob Pearce, Anna Reid, Michelle Pereira, James Freeman and Elin Gray
Edith Cowan University, Australia
Sir Charles Gairdner Hospital, Perth Australia
Fiona Stanley Hospital, Perth Australia
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
DOI: 10.4172/2155-9554-C1-057
Abstract
Current methods of melanoma diagnosis and prognosis are at times problematic and limited to observation of tumor tissue by histology or imaging. The analysis of blood based, tumor specific products including autoantibodies, circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs), now provides early rapid, accurate and quantitative measurements of tumor presence and/or burden. In our studies, we utilized protein arrays, mutation-specific droplet digital PCR and microfluidic devices to measure autoantibodies, mutant tumor DNA (ctDNA) and circulating tumor cells (CTCs), respectively, in patients with very early to advanced stage metastatic melanoma. Autoantibodies were detected in very early stage patients (n=150) at significantly higher concentrations than those in healthy controls (n=150). A diagnostic combination of 10 autoantibodies has been identified that can be utilized as an accompaniment to current clinical measures. For metastatic melanoma we utilized ctDNA and CTCs to detect and monitor tumour burden during treatment of patients with targeted therapies (n=47) and/or immunotherapies (n=48). CTCs and/or ctDNA were detected in 70% to 80% of samples prior to treatment. Levels of ctDNA and CTCs decreased in response to therapies, prior to, or concurrently with radiographic response. Moreover, patients with no, or low, levels of ctDNA and CTCs at baseline had significantly longer PFS. In addition, CTC subtypes, including those positive for PDL1, predicted response. In conclusion, our studies demonstrate the utility of blood based liquid biopsies to assist with diagnosis, prognosis and monitoring of melanoma patients.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords