Blood Pressure, Magnesium And Other Mineral Balance In Two Rat Models Of Salt-sensitive Induced Hypertension: Effects Of A Non-peptide Angiotensin II Receptor Type-1 Antagonist | 50281
Journal of Clinical & Experimental Cardiology
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The renin-angiotensin system is critically involved in regulating arterial blood pressure (BP). Inappropriate angiotensin type-1
receptor activation by angiotensin-II (Ang-II) is related to increase arterial BP. Mg has a role in BP; it can affect cardiac electrical
activity, myocardial contractility and vascular tone. To evaluate the relationship between high BP induced by a high sodium(Na)
diet and Mg and other mineral balances, two experimental rat models of salt-sensitive, induced-hypertension were used: Ang-II
infusion and Dahl salt-sensitive (SS) rats. We found that: 1) Ang-II infusion progressively increased BP, which was accompanied
by hypomagnesuria and signs of secondary hyperaldosteronism; 2) an additive effect between Ang-II and a high Na load may have
an effect on strontium (Sr), zinc (Zn) and copper (Cu) balances; 3) Dahl SSrats fed a high Na diet had a slow pressor response,
accompanied by altered Mg, Na, potassium (K), and phosphate (P) balances; and 4) losartan prevented BP increases induced by Ang
II-NaCl, but did not modify mineral balances. In Dahl SS rats, losartan attenuated high BP and ameliorated magnesemia, Na and K
balances. Mg metabolism may be considered a possible defect in this strain, which may contribute to hypertension.