alexa Bone Fragility In Diabetes Mellitus And Regulation Of Glucose Metabolism By Bone
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

5th World Congress on Diabetes & Metabolism
November 03-05, 2014 Embassy Suites Las Vegas, USA

Ippei Kanazawa
ScientificTracks Abstracts: J Diabetes Metab
DOI: 10.4172/2155-6156.S1.026
Accumulating evidence has shown that the risk of osteoporotic fractures is increased in patients with diabetes mellitus although they have normal or increased bone mineral density (BMD). Since the incidence of osteoporotic fracture is related with morbidity and mortality, it became social issue especially in industrial countries. Advanced glycation end products (AGEs) are shown to be involved in diabetes mellitus-related bone fragility. AGEs inhibits osteoblastic differentiation. Moreover, AGEs-collagen crosslinks in bone matrix weaken bone strength. Recently, it was found that cortical porosity exists in diabetic patients with history of osteoporotic fractures. In clinical settings, it is required to clarify how to detect the diabetes-related bone fragility because BMD measurement is not useful for screening. On the other hand, it is reported that bone regulates glucose metabolism vice versa. Osteocalcin produced by osteoblasts stimulates insulin secretion in pancreatic beta-cells as well as adiponectin in adipocytes, resulting in preventing impaired glucose tolerance and fat accumulation. Most recently, osteocalcin is reported to stimulate secretion of glucose-like peptide-1 in small intestine. The author will review the diabetesrelated bone fragility as well as the endocrine function of osteocalcin.
Ippei Kanazawa obtained PhD degree in 2009 from Shimane University Graduate School of Medicine and completed Postdoctoral studies at McGill University in Canada. He is now an Assistant Professor of the division of Endocrinology and Metabolism in Shimane University Faculty of Medicine. He has published more than 45 papers in international journals and serving as an Editorial Board Member of Journal of Diabetes & Metabolism.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version