alexa Bone Tissue Engineering Guided By Magnetic Forces And Magnetic Scaffolds | 24564
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

4th International Conference on Nanotek & Expo

Alessandro Russo, Michele Bianchi, Silvia Panseri, Monica Sandri, Maria Cristina Maltarello,Tatiana Shelyakova, Alessandro Ortolani, Marco Boi, Anna Tampieri, Valentin Dediu and M Marcacci
Accepted Abstracts: J Nanomed Nanotechnol
DOI: 10.4172/2157-7439.S1.019
Abstract
A major challenge is of bone tissue engineering is to regenerate bone tissue with a controlled three dimensional architecture able to reproduce the native biological and mechanical characteristics. The application of magnetic forces to orient, in vitro, the osteoblasts and the collagen fibrils according to magnetic field lines and to boost cell proliferation and differentiation has been yet demonstrated. The objective of the present study is to show that magnetic forces can guide bone tissue regeneration in a well-defined three dimensional pattern according to the applied magnetic field. 24 hydroxyapatite/collagen (70:30) scaffolds magnetized with magnetic nanoparticles according to two different magnetization methods, were implanted in both the lateral femoral condyles of 12 rabbits in contact with a permanent magnet. Nonmagnetic scaffolds were also implanted as control group. Magnetized scaffolds showed new bone tissue formation at both follow-up times (4-12 weeks) and no adverse reactions occurred. For the first time in vivo, it is also revealed that, in the presence of static magnetic field, the scaffold collagen fibrils oriented parallel to the magnetic field after 4 weeks, whereas after 12 weeks the new bone formation is oriented perpendicular to the magnetic lines compared with the random tissue regeneration showed by the control group. Nanomechanical tests have been also carried out in order to address the new bone tissue maturity at 4/12 weeks. These findings open the way to the fascinating possibility of recreating in vivo the three dimensional functional architecture of bone tissue guided by magnetic forces and magnetic scaffolds.
Biography
Alessandro Russo got his Master Degree in Medicine and Surgery in 2000 and PhD in 2009 at University of Bologna. Since 2001, he has been carrying on numerous research regarding knee prosthesis fixation and polyethylene wear by means of Roentgen Stereophotogrammetric Analysis (RSA) technique. The main field of interest is the application of nanostructured materials in orthopaedic surgery. Presently, he is orthopaedic Surgeon and Researcher at the Laboratory of NanoBiotechnologies of the Rizzoli Orthopaedic Institute, Italy.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version