BP1: A Potential Oncogene Overexpressed In Cancer | 37623
Journal of Molecular and Genetic Medicine
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BP1, a gene we identified and cloned is a member of the homeobox gene family of Transcription Factors (TF). BP1 is overexpressed
in breast cancer, prostate cancer, ovarian cancer, acute myeloid leukemia, non-small cell lung cancer and possibly other
malignancies as well. Important characteristics of BP1 in breast cancer include: (1) BP1 is expressed in 80% of invasive ductal
breast tumors including 89% of the tumors of African American women compared with 57% of the tumors of Caucasian women.
(2) BP1 expression correlates with the progression of breast tumors, from 0% in normal breast tissue to 21% in hyperplasia and
46% in ductal carcinoma in situ. (3) Expression of BP1 is associated with larger tumor size. (4) BP1 appears to be associated
with metastasis. Forty-six cases of inflammatory breast cancer were examined and all were positive for BP1 expression as well as
matched lymph nodes in the nine metastatic cases. (5) BP1 overexpression induces oncogene expression including BCL-2, VEGF
and c-MYC as well as other genes important in angiogenesis, invasion and metastasis. pBP1 down-regulates BRCA1 and (6) BP1
up-regulates ER alpha and induces estrogen independence. High pBP1 levels can lead to estrogen independence in ER positive
breast cancer cells and tumors in mice. In summary, BP1 appears to confer properties on breast cancer cells that lead to a more
invasive and aggressive phenotype. Since the functions of homeotic TF are highly conserved, it is likely that BP1 regulates many of
the same processes and genes in other malignancies.
Patricia E Berg received her Bachelor’s degree in Mathematics from the University of Chicago, her PhD in Microbiology from the Illinois Institute of Technology then pursued Post-Doctoral studies at the University of Chicago. A research at the National Institutes of Health followed. Currently, she is a Professor of Biochemistry and Molecular Medicine at George Washington University in Washington, DC where she is Director of a Cancer Research Laboratory. Her work which centers on the BP1 gene has been published in major journals and has been featured on network television and in major media including the New York Times and Washington Post.