Bradykinin Reverts Contralateral Rotation And Restores Dopamine Levels In An Animal Model Of Parkinson Disease | 64075
Journal of Neurology & Neurophysiology
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Parkinson´s disease (PD) is a neurodegenerative disorder, characterized by the loss of dopaminergic neurons in the substantia
nigra and its projections into the striatum, triggering various motor deficits. Nowadays, PD treatment mostly relies on L-DOPA
administration; however, effects produced by this drug are limited and cause diverse side effects. Treatment of PD is initiated at
advanced stages of PD, since symptoms only become evident after a loss of at least 50% of dopaminergic neurons in the substantia
nigra accompanied by a drastic reduction of dopamine content in the striatum. In view of that, the exploration of neuroprotective,
self-renewal of stem cells inducing and neuroregenerative properties of Bradykinin (BK) may help to substitute dopaminergic neuron
loss, in addition to enhancing the survival of reminiscent neurons. Recent evidence suggests that BK participates in kidney and
cardiovascular development and neuronal differentiation. Comparison between the number of rotations before (7 days after the
lesion) and after the BK or saline treatment (8 weeks): Once BK was administered after the complete establishment of 6-OHDA lesion,
we assigned the functional improvement, detected by the rotational test and the histological improvement (increased percentage of
tyrosine hydroxylase fibers) to the neuroregeneration induced by BK treatment instead of neuroprotection. Here we show that BK
exerts a neuroregenerative effect via kinin-B2 receptors in a rat model of PD induced 6-OH-dopamine injection. BK injection after
establishment of PD symptoms resulted in improvements in the lesioned areas as studied by tyrosine hydroxylase immunostaining
and motor functions.
Héllio Danny Nóbrega de Souza graduated in Biology from Federal University of Paraiba (Brazil). He completed his Master’s degree in Biochemistry from University of Sao Paulo. He is currently pursuing his PhD in Biochemistry from University of Sao Paulo. He has experience in Molecular Biology, Biochemistry and Embryology. He is presently acting on the following subjects: Development and brain formation, neural differentiation and neuroregeneration.