alexa Brazilian Natural Compound FLAV5: A Promising Anticancer Drug
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

Global Summit on Oncology & Cancer
May 25-27, 2017 Osaka, Japan

Giovanna Barbarini Longato, Yollanda Edwirges Moreira Franco, Patricia de Oliveira Carvalho, Denise Gonçalves Priolli and Claudia Quintino da Rocha
University of San Francisco, Brazil
Federal University of Maranhao, Brazil
ScientificTracks Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956-C1-099
Abstract
The high morbidity caused by cancer has required finding urgently new drugs, which can act more selectively on the cell death mechanisms. Since ancient times, plants appear as potential drugs in chemotherapy against cancer. Several native Brazilian plant species used in traditional medicine contain compounds that exhibit a broad range of therapeutic efficacy, including antitumoral activity. Arrabidaea brachypoda is a Brazilian Cerrado species widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. Its chemical profile is rich in flavonoids, compounds that present considerable scientific and therapeutic interest, being involved in the prevention of tumors and neurodegeneration. Considering these aspects, the aim of this study was to evaluate the antiproliferative activity of FLAV5 flavonoid in a panel of tumor cell lines representative of different organs and subsequently investigate the activity of this compound in the process of migration and replication of tumor cells, as well as identify its mechanism of action. The FLAV5 compound presented cytotoxic activity for the assessed tumor cell lines, being glioblastoma (U251) the most sensitive line. This compound was able to inhibit U251 cells migration, considering that after 48h of treatment only 27% of the scratch width was closed (vs. 95% control). Furthermore, FLAV5 reduced by 82% the number of colonies formed. Mechanism of action assays suggest that FLAV5 is leading tumor cells to death by inducing DNA damage. The investigation of cell signalling is being determined through western blotting technique.
Biography

Giovanna Barbarini Longato has completed her PhD at State University of Campinas-Brazil (2014) and her Post-doctoral studies at Barretos Cancer Hospital, Brazil (2015). She is a Professor at the Health Science Post-graduate program of San Francisco University-Brazil. She has experience in the area of Natural Products and Cancer and working mainly on the following subjects: Chemical and biological characterization of isolated compounds of vegetal species as well as synthesized, modified or biotransformed molecules; In vitro and in vivo antitumor activity assays; Determination of the mechanism of action of natural compounds and; Study of signaling pathways of cell death processes and pre-clinical toxicological tests of natural products.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords