alexa Breast Cancer In Patients Under The Age Of 30 Years: Clinicopathological Features And Prognosis
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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16th Global Annual Oncologists Meeting
April 24-25, 2017 Dubai, UAE

Elena Alexandrova, Sonya Sergieva and Petya Kostova
Sofia Cancer Center, Bulgaria
National Cancer Center, Bulgaria
Posters & Accepted Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956-C1-097
Abstract
Breast cancer in very young women is usually rare. A literature data showed 2% to 4.8% rate of breast cancer occurrence in women younger than 35 years. Nonetheless, we have recently observed an increasing of breast cancer in women under the age of 30 in Bulgaria. The goal of the present research is to analyse the clinicopathological characteristics of tumors in women under the age of 30. We reviewed the medical records of 107 consecutive breast cancer patients, treated through surgery in National Cancer Center from May 2012 to October 2016. The patients were divided according to age in to two groups: patients aged ≤ 30 (Group I) and patients aged 40-65 years (Group II). We collected and analysed clinical information including clinicopoathological features and treatment models. Chi-square test and multivariate analysis were used for statistical analysis. Significant differences in the clinicopathological and biological characteristics between young (≤30) and older (≥40) was found. Compared with old patients of group II, young patients have a greater tumor size at diagnosis, with a higher proportion of axillary lymph node metastases, human epidermal growth factor ( HER-2) positive expression and higher rate of local recurrence, (p<0.001). Therefore, different more aggressive treatment strategies should be applied in the cases of very young and older breast cancer patients, respectively. Subcutaneous mastectomy with immediate reconstruction is probably an appropriate surgical treatment for the youngest breast cancer patients. Combination of certain unfavourable tumor characteristics in these patients suggest the possibility of some differences in biology and pathogenesis of breast cancer which may exist between very young and older women. These issues could be subject of further investigations.
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