To study the relationship between serum DNA and breast cancer proliferative activity, and then compare the diagnostic and
prognostic value of serum DNA, TPS and CEA.
Subjects and Methods:
A total of 100 breast cancer patients before surgery and 50 normal healthy controls were analyzed for
serum DNA, TPS and CEA.
Serum DNA levels were non-significantly correlated with serum TPS levels. Serum DNA, TPS and CEA levels were
significantly higher in patients than controls. Using ROC curve analysis, serum TPS and DNA had the highest AUC compared
to serum CEA. Neither serum TPS, DNA nor CEA correlated with breast cancer clinicopathological data. Only serum CEA was
significantly correlated with patients' disease-free survival, but serum DNA and TPS did not show this correlation.
Neither Breast cancer mass nor proliferative activity is the source of free serum DNA. Serum TPS is superior to DNA
and CEA as a diagnostic marker for breast cancer. Only preoperative serum CEA has a prognostic role in predicting relapse of
breast cancer patients, but not serum TPS and DNA.
Taha Ismail Hewala has completed his Ph.D. at the age of 31 years from Alexandria University and Assistant Professor in the field of cancer
diagnosis and therapy at the age of 36 from Alexandria University. He is the Head of Radiation Sciences Department, Medical Research Institute,
Alexandria University. He has published 8 papers in different international and local journals.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals