alexa Bridging The Gap Between Animal Models And Clinical Trials: The Use Of In Vitro Assays To Accelerate Cancer Immunotherapy Development | 69739
ISSN: 2471-9552

Immunotherapy: Open Access
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2nd International Conference on Tumor & Cancer Immunology and Immunotherapy
July 17-18, 2017 Chicago, USA

Sofie Pattijn, Brecht Hoedemaekers, Séverine Giltaire, Juliette Lamy and Thibault Jonckheere
ImmunXperts SA, rue Auguste Piccard 48, 6041 Gosselies, Belgium
Posters & Accepted Abstracts: Immunotherapy (Los Angel)
DOI: 10.4172/2471-9552-C1-006
Abstract
During the last years, significant advancement has been made in the clinical application of cancer immunotherapies. Molecules directed against immune checkpoints and other agonists show great promise for treatment of a variety of malignancies. Next to CTLA-4 and PD-1 blockade, a wide range of therapeutics with the potential to reverse the tumorinduced suppression are under development. Early evaluation of the effectiveness of candidate therapeutics and combination therapies can be done using mouse models and in vitro bioassays with human immune cells. Mixed lymphocyte reaction assays using both innate cells and lymphoid cells mimic a real physiological T cell response and are widely used for the potency screening of candidate therapeutics. The use of different allogenic donor combinations can provide additional information on the profile of the responding population. An important factor for sensitive assays and consistent results is the quality of the primary immune cells. PBMC are isolated and cryopreserved shortly after blood redrawn. All donor preparations are quality controlled and HLA typed and optimized procedures are used to generate functional dendritic cells which are co-cultured with allogenic T cells. Response levels can be evaluated by the assessment of proliferation or measurement of cytokine production. Next to the MLR assay, other T cell assays such as antigen-specific recall activation assays can be used to evaluate the ability of test molecules to promote T cell responses. In addition to T cell assays, macrophage polarization assays are an essential tool to evaluate metabolic or other reprogramming functions of test compounds.
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