Caffeic Acid Phenethylester Inhibits Epithelial?mesenchymal Transition, Proliferation And Migration In Human Prostate Cancer Cells | 27443
Journal of Cancer Science & Therapy
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Most prostate cancer-associated deaths are due to the metastatic disease. Targeting prostate cancer cell migration may lead to
new approach to treat and/or prevent metastatic prostate cancer. Increasing evidence has shown that epithelial mesenchymal
transition (EMT) plays a pivotal role in promoting cancer metastasis. Thus targeting EMT represents a potential therapeutic approach
to slow down or prevent metastatic spread. Caffeic acid phenethyl ester (CAPE), one of major bioactive components of propolis was
reported to have the ability to suppress the EMT in pancreatic cancer. In this study, we investigated the preventive and inhibitory
effect of CAPE on EMT inprostate cancer cells in vitro and in vivo. Our results indicated that the cell migration and proliferation were
significantly inhibited in a dose-dependent manner in prostate cancer cell lines PC3, DU145 and C4-2. By analyzing the expression
of EMT markers, we observed the enrichment of epithelial phenotypes, including E-cadherin, ?-catenin and/or Claudin-1 and
suppression of mesenchymal phenotypes including Vimentin, Snail-1 and/or Slug in PC3, DU145 and C4-2 cells treated with CAPE.
In vivo studies also showed fewer tumor cells in the lung tissues of CAPE treated mice as compared with vehicle treated controls.
Induction of E-cadherin and down regulation of Vimentin was also observed in the lung tissue of treatment group. Taken together
these results suggest that CAPE suppression of prostate cancer metastasis is in part mediated through inhibition of EMT, proliferation
and migration of human prostate cancer cells.
Jiang Tian is currently working as a Postdoctoral associate in Department of Urology, University of Pittsburgh School of Medicine. He received his MD degree from Hebei
Medical University in 2005 and Master degree and PhD degree from Sun Yat-sen University in 2008 and 2011 respectively. His research interest is in studying some dietary
bioactive compounds to prevent and inhibit cancer cell growth.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals