alexa Can Brevibacillus A Soil Microbe Transmuted Into A Possible Uropathogen?
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Congress on Bacteriology & Infectious Diseases
November 17-19, 2014 DoubleTree by Hilton Hotel Chicago-North Shore, USA

Suneeva Sharon Christa A and Pragasam Viswanathan
ScientificTracks Abstracts: J Bacteriol Parasitol
DOI: 10.4172/2155-9597.S1.006
Abstract
The evolved pathogenic strains differ from their commensal counterparts through the expression of the virulence factors exploit the host to elicit an infection. This study determines the possible mechanism on how an aerobic soil bacterium, from urinary tract infected subject, was capable of causing an infection in vivo. The urinalysis from the urinary tract infected subject tested negative for nitrite, leukocyte, hematuria and bacteriuria. However a significant number of bacteria were isolated upon incubation for 24 h that were susceptible to amoxicillin-clavulunate (30 mcg), cotrimoxazole (25 mcg) and tetracycline (30 mcg). The isolated strain was characterized phenotypically; a phylogenetic tree was constructed using the 16S rRNA sequence obtained from the strain and it exhibited 99% similarity with the Brevibacillus agri AB112716 strain. From the compartitative validation of the phenotypic characteristrics using a standard Brevibacillus agri and an uropathogenic E. coli (CFT073) strain, the isolated Brevibacillus RRL-01, was speculated to be an uropathogen. An experimental mouse model was generated by transferring 2.5x108 cfu of the strain by trans-urethral catheterization. Mortality was observed in the infected animals two hours post infection. The tissues were harvested and processed for histopathological analysis. The presence of the bacilli in tubular pockets along with the destruction of glomerular and tubular morphology with prominent haemagglutiation was observed in the H&E stained sections. This study concludes based on the phenotypic characteristics and the histopathological analysis that this soil microbe could have undergone genotypic modification to cause UTI, which have to be elucidated by further in-depth genomic analysis.
Biography
Suneeva Sharon Christa A is a doctoral degree student who works with Dr. Pragasam Viswanathan, at Renal Research Laboratory, VIT University, Vellore. Her doctoral work focuses on the regulation of renal antimicrobial proteins and inflammatory markers in experimental pyelonephritic model and has been published in peer-reviewed journals. She has an experience of working with various animal models of the renal system and on the production and purification of antibodies for proteins of renal origin.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords