alexa Cancer Gene Somatic Mutation Detection-A Tool For Personalized Cancer Therapy
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd World Congress on Cancer Science & Therapy
October 21-23, 2013 DoubleTree by Hilton Hotel San Francisco Airport, CA, USA

Michael J. Powell
ScientificTracks: J Cancer Sci Ther
DOI: 10.4172/1948-5956.S1.028
Abstract
Substantial advances have been made in understanding critical molecular mechanisms driving tumor initiation, maintenance, and progression in many types of cancer. Specifically, allelic variations in cancer-related genes result in the expression of proteins that can affect the sensitivity of tumors to targeted therapeutics. For example, non-small cell lung cancer (NSCLC) tumors that express activating alleles of the Epidermal Growth Factor Receptor (EGFR) are more sensitive to EGFR kinase inhibitors such as Tarceva. Conversely, in metastatic colorectal cancer, activating alleles of the KRAS gene render tumors resistant to EGFR inhibitors. Furthermore, drugs that target specific allelic variants of cancer related targets have recently become available such as Vemurafenib that inhibits activated B-Raf in melanoma and potentially other forms of cancer. The challenge is that theseallelic variants often exist in a small minority (<1%) of tumor cells making direct sequencing of tumor DNA impractical. There is a need for simple and robust methodologies to quickly identify important mutations in cancer related genes. In this presentation I will review the available technologies for cancer gene mutation detection and describe a new technology that can rapidly and accurately identify allelic variants in as little as 0.1% of tumor cells. The technology will allow the rapid screening of a patients tumor to provide the oncologist with information to use in the selection of appropriate therapy and treatment regimen on a patient specific basis.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords