alexa Cancer Stem Cells In Oral Tongue, Lip And Buccal Mucosal Squamous Cell Carcinoma Express Components Of The Renin-angiotensin System
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

10th International Conference on CANCER STEM CELLS AND ONCOLOGY RESEARCH
June 26-28, 2017 London, UK

Swee T Tan
Gillies McIndoe Research Institute, New Zealand
Keynote: J Cancer Sci Ther
DOI: 10.4172/1948-5956-C1-101
Squamous cell carcinoma (SCC) makes up more than 90% of cancer affecting the oral cavity including the oral tongue, buccal mucosa, floor of mouth, retromolar trigone, hard palate, alveolus and the lip. Treatment of oral cavity SCC (OCSCC) typically involves surgical resection, often followed by radiotherapy, and sometimes biologic agents. Despite this radical treatment, the 5-year survival rate for SCC affecting most oral cavity subsites has remained at 50% for the past 4 decades. Cancer stem cells (CSCs) have been identified in many types of cancers including OCSCC. Our recent data demonstrates the presence of 3 different putative CSC subpopulations within SCC of the oral tongue, buccal mucosa and lip. We have also demonstrated these CSC subpopulations express components of the renin-angiotensin system (RAS). We ahve also shown that the CSCs in one of these cancers studied (oral tongue SCC) also express the protease cathepsins B, D and G (CathG), suggesting the existence of potential bypass loops for the RAS. Our work suggests CSCs as a novel therapeutic target by modulation of the RAS using existing medications.

Swee T Tan is the Director of the Gillies McIndoe Research Institute in Wellington, New Zealand. He completed his Medical Training at Melbourne University in 1985, Plastic Surgery Training in New Zealand in 1992, and gained a PhD from Otago University in 2001. In 1995, he was appointed as Consultant Plastic & Cranio-Maxillofacial Surgeon at the Wellington Regional Plastic, Maxillofacial & Burns Unit at Hutt Hospital, where he was the Director of Plastic Surgery from 2000 to 2006 and Director of Surgery 2007-2013. He was appointed as Professor in Plastic Surgery at Otago University in 2008. He is the Founder and Director of the Centre for the Study & Treatment of Vascular Birthmarks, a national referral centre. He has received numerous honours and awards and is well known internationally for his research into the stem cell basis of diseases including vascular anomalies and cancer. He is the author of more than 140 publications and has delivered over 350 lectures at conferences.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version