alexa Cardioprotective Effects Of β-sitosterol From Linum Usitatissimum Against Isoproterenol-induced Myocardial Infarction In Rats: A Biochemical, Electrocardiographic And Histological Features
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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9th Annual European Pharma Congress
June 26-28, 2017 Madrid, Spain

Amal Derbali, Kais Mnafgui and Abdelfattah Elfeki
University of Sfax, Tunisia
Posters & Accepted Abstracts: Pharmaceut Reg Affairs
DOI: 10.4172/2167-7689-C1-025
Abstract
Myocardial infarction (heart attack) is the irreversible death (necrosis) of heart muscle secondary to prolonged lack of oxygen supply (ischemia). The present study was designed to evaluate cardioprotective effect of β-sitosterol, the major sterol of flaxseed oil, Linum usitatissimum, against isoproterenol induced myocardial infarction in rats. The research started with evaluating the sterol composition of Linum usitatissimum. Then, studying cardiovascular protective effect of its major sterol, β-sitosterol is based on cardiac damage markers especially electrocardiographic changes, histopathological modifications, troponin T and total cholesterol serum level. According to chemical analysis, this extract is composed essentially of stigmasterol (10.45%), avenasterol (13.30%), campesterol (25.33%) and β-sitosterol (44.08%). Male rats were randomly divided into four groups namely control (C), isoproterenol (ISO), isoproterenol treated group with clopidogrel (0.1 mg/kg body weight of clopidogrel/day) (CLO+ISO) and group treated with β-sitosterol (40 mg/kg body weight/day) (BS+ISO). Isoproterenol injection showed changes in electrocardiographic patterns, including ST-segment elevation. It caused the increase of the serum levels of troponin T and other cardiac injury biomarkers with antihypertensive effect through inhibition of angiotensin converting enzyme serum level. It also leaded to the appearance of edema and necrosis in myocardial tissue. However, β-sitosterol pre-co-treatment prevented almost all the parameters of isoproterenol-induced myocardial infarction in rats. To conclude, β-sitosterol, which is the active sterol of flaxseed oil, has a significant cardioprotective effects against isoproterenol-induced myocardial infarction.
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