alexa Cardioprotective Effects Of β-sitosterol From Linum Usitatissimum Against Isoproterenol-induced Myocardial Infarction In Rats: A Biochemical, Electrocardiographic And Histological Features
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

9th Annual European Pharma Congress
June 26-28, 2017 Madrid, Spain

Amal Derbali, Kais Mnafgui and Abdelfattah Elfeki
University of Sfax, Tunisia
Posters & Accepted Abstracts: Pharmaceut Reg Affairs
DOI: 10.4172/2167-7689-C1-025
Abstract
Myocardial infarction (heart attack) is the irreversible death (necrosis) of heart muscle secondary to prolonged lack of oxygen supply (ischemia). The present study was designed to evaluate cardioprotective effect of β-sitosterol, the major sterol of flaxseed oil, Linum usitatissimum, against isoproterenol induced myocardial infarction in rats. The research started with evaluating the sterol composition of Linum usitatissimum. Then, studying cardiovascular protective effect of its major sterol, β-sitosterol is based on cardiac damage markers especially electrocardiographic changes, histopathological modifications, troponin T and total cholesterol serum level. According to chemical analysis, this extract is composed essentially of stigmasterol (10.45%), avenasterol (13.30%), campesterol (25.33%) and β-sitosterol (44.08%). Male rats were randomly divided into four groups namely control (C), isoproterenol (ISO), isoproterenol treated group with clopidogrel (0.1 mg/kg body weight of clopidogrel/day) (CLO+ISO) and group treated with β-sitosterol (40 mg/kg body weight/day) (BS+ISO). Isoproterenol injection showed changes in electrocardiographic patterns, including ST-segment elevation. It caused the increase of the serum levels of troponin T and other cardiac injury biomarkers with antihypertensive effect through inhibition of angiotensin converting enzyme serum level. It also leaded to the appearance of edema and necrosis in myocardial tissue. However, β-sitosterol pre-co-treatment prevented almost all the parameters of isoproterenol-induced myocardial infarction in rats. To conclude, β-sitosterol, which is the active sterol of flaxseed oil, has a significant cardioprotective effects against isoproterenol-induced myocardial infarction.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords