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Carotenoids: The Most Potent Phytochemicals In Nature Having Health Promoting Activities | 7565
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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Carotenoids: The most potent phytochemicals in nature having health promoting activities

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

Ravendra P.S. Chauhan, Charu Gupta and Dhan Prakash

Accepted Abstracts: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.008

Eletriptan hydrobromide is a potent anti-migraine drug. The purpose for the present investigation is to formulate and evaluate proniosomal nasal drug delivery system of eletriptan hydro bromide using coacervation phase separation method. Proniosomes are prepared using various non-ionic surfactants like span 80, tween 80 and combination of both span and tween with or without cholesterol from 0 to 50%. the effect of non-ionic surfactant and cholesterol was identified. The drug release from the prepared system was carried out and was compared with eletriptan hydrobromide tablets (Relpax tablets). Further the niosomes prepared where also tested for entrapment efficiency, rate of hydration, vesicle size and in-vitro analysis. The entrapment efficiency was found to be 47.9+0.96%. The niosomes released 58.91% eletriptan hydrobromide over a period of 5h and 78.1% of the drug was absorbed from the nasal mucosa.
S N Kilikar has completed his graduation in Chemistry from Kerala University, India in the year 1973. He is having an experience in Pharmaceutical Industry for more than 37 years in the field of QC, PRODUCTION and GMP Implementation including Validation. Now he is working as a consultant to support Pharmaceutical units to develop new Facilities, Documentation, Validations and other cGMP requirements. He is conducting many Training programmes including for sterile manufacturing. Technical audits are conducted to rectify and upgrade the systems to cGMP level. Three AYURVEDA manufacturing units are set up in Kerala conforming to cGMP standards.
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