Eletriptan hydrobromide is a potent anti-migraine drug. The purpose for the present investigation is to formulate and
evaluate proniosomal nasal drug delivery system of eletriptan hydro bromide using coacervation phase separation method.
Proniosomes are prepared using various non-ionic surfactants like span 80, tween 80 and combination of both span and tween
with or without cholesterol from 0 to 50%. the effect of non-ionic surfactant and cholesterol was identified. The drug release
from the prepared system was carried out and was compared with eletriptan hydrobromide tablets (Relpax tablets). Further
the niosomes prepared where also tested for entrapment efficiency, rate of hydration, vesicle size and in-vitro analysis. The
entrapment efficiency was found to be 47.9+0.96%. The niosomes released 58.91% eletriptan hydrobromide over a period of 5h
and 78.1% of the drug was absorbed from the nasal mucosa.
S N Kilikar has completed his graduation in Chemistry from Kerala University, India in the year 1973. He is having an experience in Pharmaceutical
Industry for more than 37 years in the field of QC, PRODUCTION and GMP Implementation including Validation. Now he is working as a consultant
to support Pharmaceutical units to develop new Facilities, Documentation, Validations and other cGMP requirements. He is conducting many
Training programmes including for sterile manufacturing. Technical audits are conducted to rectify and upgrade the systems to cGMP level. Three
AYURVEDA manufacturing units are set up in Kerala conforming to cGMP standards.
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