Carvacrol Ameliorates The PPAR-α And Cytochrome P450 Expression On D-galactosamine Induced Hepatotoxicity Rats | 16524
Journal of Molecular Biomarkers & Diagnosis
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arvacrol (2-methyl-5-(1-methylethyl)-phenol) is a predominant monoterpenic phenol which occurs in many essential oils
of the family Labiatae including Origanum, Satureja, Thymbra, Thymus, and Corydothymus species. It is well known for its
anti-inflammatory, antioxidant and antitumor activities. The present study investigates the influence of carvacrol on CYP2E1
and PPAR-α on D-GalN-induced hepatotoxic rats. The mRNA and protein expression levels of CYP2E1 and PPAR-α have been
assayed by semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and western blot analysis. We found
that the mRNA and protein expressions of CYP2E1 significantly up-regulated while the mRNA and protein expressions of
PPAR-α significantly down-regulated on D-galactosamine induced hepatotoxic rats and treatment with carvacrol significantly
suppressed the mRNA and protein expressions of these genes. Thus, the present results have shown that carvacrol has the
hepatoprotective effect and also alleviates liver damage associated with GalN induced hepatotoxic rats by down-regulating the
CYP2E1 and up-regulating the PPAR-α expression.
Balakrishnan Aristatile is an Assistant Professor in the Department of Food Science and Nutrition, College of Food and Agricultural Science, King Saud University,
Saudi Arabia. He has done his Ph.D. in Biochemistry. His area of research is Molecular mechanism and phytochemicals treatment in the prevention of hyperlipidemia
and herbal medicine. He is a member of Society of Biological Chemists of India, Society for Free Radical Research - India (SFRR- India), Indian Society of
Atherosclerosis Research (ISAR) - India and Indian Science Congress, India.
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