Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Michelle Alpino Bittencourt
Paran�?�?�?¡ Health Care, Brazil
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
Jorge Lobo's disease is a chronic cutaneous and subcutaneous granulomatous fungal infection caused by Lacazia loboi. It was first described by a brazilian dermatologist named Jorge Lobo in 1931. Most human cases are restricted to tropical regions predominantly in the Amazon. Transmission seems to occur through traumatic inoculation of the fungus, consequently the lesions usually occur on the skin of the lower extremities exposed areas. In the present study, we report a case of an infected patient who is resident in the North of Mato Grosso, Brazil. In the literature review of Jorge Lobo�?¢�?�?�?�?s disease, we noticed that the clinical presentation is usually polymorphic, with the lesion initially imperceptible, altering over time in size, color and distribution. The diagnosis is made by mycological, clinical, pathological and immunohistochemical examination. So far, it has not been possible to isolate this fungus in culture which makes it difficult to understand the immunological aspects involved in the disease and makes it difficult to know the mechanisms that favor the spread of mycosis and how it occurs. The choice of treatment depends on the distribution of the lesions. A good therapeutic for small or isolated lesions has been surgical excision or cryotherapy treatment. In the present case, considering the extent of the lesion, pharmacological treatment with clofazimine and itraconazole was chosen. After observing the clinical course for about ten months, there was no significant improvement of the cutaneous lesions. For correct and early diagnosis and for the best treatment it is essential to know that this disease is increasingly common outside the tropics. The rarity associated with treatment failures based on extensive review of the literature disease motivated the research regarding the subject and the description of the asssited case.
Email: bittenmic@yahoo.com