alexa Catalytic Asymmetric Synthesis Of Biologically Active Natural Products
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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International Conference on Stereochemistry
August 18-19, 2016 Sao Paulo, Brazil

Takumi Watanabe
Institute of Microbial Chemistry -BIKAKEN, Japan
ScientificTracks Abstracts: Med chem
DOI: 10.4172/2161-0444.C1.021
Abstract
Catalytic asymmetric synthesis of caprazamycin B an anti-tuberculosis natural product, and a key synthetic intermediate for scytophycin C a cytotoxic marine natural product, was completed. In order to furnish the key stereochemical elements, both syntheses employed the catalytic asymmetric reactions developed by Shibasaki and coworkers: thioamide-aldol reaction, antiselective nitroaldol reaction, and alcoholysis of 3-methylglutaric anhydride, namely.
Biography

Takumi Watanabe obtained Master degree from The University of Tokyo, and joined Institute of Microbial Chemistry as a Researcher in 1993. Then, he received PhD degree in 2000, and was promoted to the laboratory Head of Laboratory for Synthetic Organic Chemistry at the same Institute in 2015. He joined ETH as a Post-doctoral fellow (Prof. Erick M. Carreira) from 2002 to 2004.

Email: [email protected]

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