alexa
Reach Us +441414719275
Cell Therapy For Muscle Injuries | 9624
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Cell therapy for muscle injuries

2nd International Conference on Tissue Science & Regenerative Medicine

Tracy Criswell

Symposium: J Tissue Sci Eng

DOI: 10.4172/2157-7552.S1.010

Abstract
S keletal muscle injuries are a major cause of disability, loss of mobility and quality of life. Current treatments for severe muscle dysfunctions are insufficient and cell therapy using adult muscle precursor cells (MPCs) provides a novel therapeutic approach. Recent preclinical and clinical data on MPC therapy show little to no effect on muscle function recovery. Using a rat model of muscle injury, we have demonstrated the ability of MPCs to survive, proliferate, differentiate and integrate with host myofibers and tissue of young animals. Despite the continued presence of the cells, little functional improvement was detected. However, differential effects of MPC therapy were detected between young and older animals, and male and female animals, with and without cell therapy. This data demonstrates that age- and gender-dependent differences in muscle regeneration must be considered when designing cell therapy approaches.
Biography
Criswell is a junior faculty member at the Wake Forest Institute for Regenerative Medicine and the Wake Forest Sticht Center on Aging. She is a cell and molecular biologist with vast experience in growth factor research and cell signaling pathways, in regards to skeletal muscle biology, physiology and regeneration. Her specific interests are in exploring the cellular and micro-environmental ?cues? that regulate skeletal muscle regeneration after injury and are differentially expressed due to age and gender, in order to develop novel therapies for the restoration of muscle function in the aged population.
Top