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Sylvia Lee-Huang, Philip Lin Huang and Paul Lee Huang
New York University School of Medicine, USA Harvard University, USA
Posters & Accepted Abstracts: J AIDS Clin Res
Dr. Sylvia Lee-Huang is a Professor of Biochemistry and Molecular Pharmacology at New York University School of Medicine, in New York, New York, USA. Dr. LeeHuang received her Ph.D. in Biophysics from the University of Pittsburgh with Professor Gary Felsenfeld. She did her post-doctoral research with Dr. Liebe Cavalieri at the Sloan-Kettering Institute for Cancer research. She started her academic research with Nobel Laurate Professor Severo Ochoa at NYU School of Medicine, Department of Biochemistry, in Molecular Biology and Biochemistry. Professor Lee-Huang has a broad background in biochemistry, biophysics, cell biology, molecular biology, molecular genetics and virology. As a graduate student, she studied the interactions of DNA, RNA and protein with Dr. Gary Felsenfeld, laying the groundwork for nucleic acid interactions. As a postdoctoral fellow, she studied the mechanism of DNA replication with Dr. Liebe Cavalieri. She proposed the first concept and provided the first experimental evidence for the reversed flow of genetic information from RNA to DNA. Her work challenged and revolutionized the “central dogma” in gene expression. As a research associate with Nobel laureate Professor Severo Ochoa, she studied the regulation of gene expression and discovered small RNAs act as inhibitors and activators in gene expression. This work laid the concept for small regulatory RNAs including today’s RNAi, miRNA and lncRNA. As a PI on NIH-grants, her lab was the first to clone and express human erythropoietin. Recently, her lab studied the mechanism of anti-HIV compounds. Her team isolated, purified, characterized and elucidated the mechanism of anti-HIV proteins, oligopeptides and small molecules. Her work has been published in major journals, including Cell, Nature, Science, PNAS, Biochemistry (JACS), BBRC and others.
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