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Background: Klotho is recognized as an anti-aging protein, protects the
cardiovascular system through endothelium derived NO. Klotho deficiency
disturbs endothelial integrity but the molecular mechanism is not fully clarified.
Objective: The objective of this study was to observe the relationship between
Klotho protein and biochemical marker of oxidative stress, endothelial
dysfunction and arterial aging in non-treated and ACEI-treated patients with
essential hypertension (EH).
Subjects & Methods: Eighty subjects with essential hypertension, divided into
two groups and the first didn???t receive any hypertensive treatment (n=40) while
the other (n=40) received angiotensin converting enzyme inhibitors (ACEIs) and
20 age and sex matched controls were included in the study. Serum levels of nitric
oxide (NO), malondialdehyde (MDA), vascular endothelial growth factor-A
(VEGF-A) and Klotho protein were measured. Carotid Intima-Media Thickness
(CIMT) was determined by ultrasonography for all participants.
Results: Mean values of MDA, VEGF-A and CIMT revealed significant increment while those of NO and Klotho showed
significant reduction in non-treated EH patients compared to controls. Mean levels of MDA, VEGF-A and CIMT showed
significant reduction while those of NO and Klotho exhibited significant elevation in ACEI-treated patients compared to
corresponding values of non-treated ones. Significant negative correlation between serum MDA concentration and NO levels
and positive correlation between Klotho level and NO were observed in the present study.
Conclusion: Soluble Klotho may become an important target in vascular medicine, mainly in situations where senescence
and stress are responsible for accelerated vascular damage in hypertension. The addition of exogenous Klotho may prevent the
oxidative stress that induces premature senescence.
Wafaa Mahmoud Abdel-Rehim works as Assistant Professor of Biochemistry at Medical Research Institute under Alexandria University, Egypt. She published more than 20 papers in reputed journals including Journal of Cellular Biochemistry in 2017 and Biological Chemistry in 2016.