Changes Of Muscle FGF-6 Expression At Different Time Points After Exercise-induced Muscle Damage | 9350
Journal of Computer Science & Systems Biology
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The aim of this study was to investigate the expression of muscle fibroblast growth factor-6 (FGF-6) and explore the
relationship with skeletal muscle regeneration and repair after exercise-induced muscle damage (EIMD)
Reverse transcription-PCR and immunohistochemistry staining was utilized to examine FGF-6 mRNA and protein
expression in rat at different time points(0h, 6h, 12h, 1d, 2d, 3d, 1w, 2w) after a bout of downhill treadmill running( 90min, -16m/
min speed and -16?slope,). The status of muscular injury and regeneration was assessed by HE (hematoxylin-eosin staining)
Skeletal muscle appeared the worst damage 3d post-running with a profusion of inflammatory cells. After 2w the
regenerated myofibers could be distinguished. The FGF-6 protein expression showed an initially elevation, then followed by a
gradual reduction, while the expression of FGF-6 mRNA remained elevation after exercise.
Our results point out that FGF-6 is closely related to skeletal muscle regeneration and repair, probably implying a
dual function in muscle regeneration.
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