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A3D multiscale particle-cell hybrid model and a microfluidic platform are developed
to model nanoparticle transport, dispersion, and adhesion dynamics in blood
suspension. The motion and deformation of red blood cell is captured through Immersed
Finite Element method. The influences of vascular flow rate, geometry, nanoparticle
shape and size on nanoparticle distribution and delivery efficacy are characterized. . A
non-uniform nanoparticle distribution profile with higher particle concentration near
the vessel wall is observed. Such distribution leads to 50% higher particle binding rate
compared to the case without RBC considered. The tumbling motion of RBCs in the
core region of the capillary is found to enhance nanoparticle dispersion. The modeled
binding results are validated through designed experiments in microfluidic devices.
Results from this study contribute to the fundamental understanding and knowledge
on how the particulate nature of blood and nanoparticle influences for nanoparticle
delivery efficiency, which will provide mechanistic insights on the nanomedicine design
for targeted drug delivery
Liu received my PhD degree from Northwestern University in 2006. His primary research interest is
on particulate and interfacial phenomena at the micro/nano scale and in biological systems. Liu have
produced 23 peer-reviewed manuscripts, 6 book chapters, and numerous conference proceedings. He
also serves as a reviewer for various peer-reviewed journals and a grant reviewer for NSF and NIH.
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