alexa Chemical Constituents Of Sandbox Tree (Hura Crepitans Linn) And Anti-hepatotoxic Activity Of The Leaves And Stem Bark Extracts
ISSN: 2161-0444

Medicinal Chemistry
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

5th International Conference on Medicinal Chemistry & Computer Aided Drug Designing and Drug Delivery
December 05-07, 2016 Phoenix, USA

Ganiyat K Oloyede, Oluwatosin A Adaramoye and Mutairu B Olatinwo
University of Ibadan, Nigeria
Posters & Accepted Abstracts: Med chem
DOI: 10.4172/2161-0444.C1.028
Abstract
Background: The use of natural products derived from plants for therapeutic purpose is as ancient as human civilization. Sandbox tree, Hura crepitans L. (Euphorbiaceae) is one of such plants and has been reported to have many ethno-medicinal applications especially as antimicrobial, anti-inflammatory and anti-hepatotoxic effects. Purpose of the study: This recent study was designed to determine the anti-hepatotoxic activity of the ethylacetate soluble fraction of the leaves and stem bark of H. crepitans and to isolate secondary metabolites. Methods: Chromatographic technique was used for isolation and Ultraviolet-Visible (UV), Infra-red (IR) and Nuclear Magnetic Resonance (NMR) spectroscopies were used for structural elucidation. Anti-hepatotoxicity study was carried out using carbon tetrachloride (CCl4) induced rat model and biochemical parameters: alanine aminotransferase (ALT), aspartate aminotransferase (AST), L-γ-glutamyltransferase (GGT), urea and creatinine (CREA) were assayed on the serum. Phytomicrographs of the liver samples were also taken and analyzed. Results: Our present study showed that biochemical studies of blood samples of CCl4 treated rats with value 105.0±0.001 AU in ALT showed significant increase in the level of serum enzyme activities reflecting liver injury but, 69.0±13.23 AU for leaves and 53.3±2.52 AU for bark (p<0.05) indicated protection of hepatic cells. AST, GGT, urea and CREA also reduced significantly. Daphnane diterpenes, daphnetoxin acid and huratoxin were isolated from H. crepitans in this recent study along with apocynin and methylpentadecanoate. Conclusion: H. crepitans significantly reduced the level of biochemical parameters indicating protection against hepatocellular injury. Isolates obtained from this plant could also serve as lead compounds in therapy of diseases involving hepatic injury.
Biography

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version