alexa Chemical Modification Of Anticancer Parasporins For Decreasing Their Toxicity
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

5th World Congress on Bioavailability and Bioequivalence Pharmaceutical R&D Summit
September 29-October 01, 2014 DoubleTree by Hilton Baltimore-BWI Airport, USA

Almas Okassov
ScientificTracks Abstracts: J Bioequiv Availab
DOI: 10.4172/0975-0851.S1.017
Abstract
S ince the discovery of cancerolytic parasporins of bacterial origin the search for its new parasporal analogs inclusions produced by non-studied strains of B. thuringiensis and reveal of their mechanism of action as candidates for antitumor drugs with low toxic activity in vivo are carried out. The scheme proposed for modification of antitumor parasporins is based on more high permeability of vessels for high molecular compounds in foci of tumorigenesis with high concentration of proteases. This condition permits to create the construction composed from active parasporin coupled with a linker particle having diameter of 40-50 nm via a peptide bridge. Proteinous nature of parasporins and revealed amino acid sequences give the possibility to insert cysteine residue into the non-functional domain aimed to use its SH-group for coupling with CO2H group of the peptide via thioester bond. Coupling the peptide with the linker is performed by NH2 group via carbamate bond. Selective delivery of these conjugates to the foci of tumor formation with further proteolytic activation should decrease therapeutic dose of the active substance and decrease concentration in normal healthy organs and tissues with common vascular permeability and resulting in decreasing of general negative effect for the organism. This methodological approach could be used for modification of known antitumor and anti-inflammatory drugs for their targeted delivery and decrease of toxic activity's level
Biography
Almas Okassov is completing his PhD dissertation in Kazakh National University in Almaty, Kazakhstan. The title of his work is ?Obtaining and analysis of parasporins as new cancerolytic agents pretentious origin?. He has 4 papers in peer reviewed journals. He holds the position of the Senior Scientist in laboratory of biotechnology at the Scientific Centre for Anti-Infectious Drugs
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords