Pharmaceutica Analytica Acta

Chitosan as potential excipient for buccal delivery

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

Flavia Laffleur

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Abstract Summary: Biomaterials have gained immense interest in the pharmaceutical research in the last decades. Chitosan is a polysaccharide which was chemically modified in order to achieve and establish a promising platform for buccal drug delivery. Introduction: Pharmaceutical scientists face challenges of a suitable delivery route. Although invasive administration has been a common route for peptide and protein drug delivery, it is associated with infections, pain on repeated administration leading to poor patient compliance. Being administered by the gastrointestinal route, peptide and proteins exhibit poor bioavailability owing to gastric acid hydrolysis and first pass metabolism. Furthermore, non-invasive routes have been investigated for systemic delivery. The mucosal delivery bears many advantages such as targeting a specific tissue, avoiding the first pass metabolism and protection against enzymatic degradation. Conclusion: Within the present study a preactivated thiolated chitosan matrix for non-invasive drug delivery was developed. The covalent attachment of preactivated thiol groups to thiolated chitosan leads to strongly improved mucoadhesive properties of the thiolated polymer, which is verified by rotating cylinder studies on freshly excised porcine mucosa and by the increase in the total work of adhesion in tensile studies. Because of this slightly chemical modification the swelling behavior of thiolated chitosan could also be improved. This property might be of considerable advantage for applications requiring mucoadhesive and long lasting properties. These features should render preactivated thiolated chitosan as useful therapeutic excipient for various dosage forms providing an improved stability and a prolonged residence time on mucosal tissues. The preactivated thiolated chitosan described within this study raises the bar according to its high mucoadhesive potential as therapeutic agent.