alexa
Reach Us +441414719275
Chitosan-based Self-healing Hydrogel: Preparation And Bio-applications | 9650
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Chitosan-based self-healing hydrogel: Preparation and bio-applications

2nd International Conference on Tissue Science & Regenerative Medicine

Lei Tao, Yaling Zhang, Bin Yang, Changkui Fu and Yen Wei

Accepted Abstracts: J Tissue Sci Eng

DOI: 10.4172/2157-7552.S1.012

Abstract
A new chitosan-based biocompatible self-healing hydrogel system has been developed. The hydrogel was achieved readily through the formation of Schiff base linkage between the amino groups on chitosan and the benzaldehyde groups on a telechelic PEG chain ends. The Schiff base is a dynamic linkage, thus the crosslink points in the hydrogel keep open and close all the time. Therefore, this hydrogel is self-healable and its gelation state can be altered by many external stimuli, such as pH, vitamin B6 derivative, some enzymes and amino acids, making it possible for controlled drug delivery applications. We have also found that this hydrogel is biocompatible, suitable for 3D cell proliferation, tissue engineering and cell free protein expression. Because of its self-healability, the hydrogel containing cells is injectable that could help fix cells at targeted positions for therapeutic. In addition, the system could also be further modified with magnetic nanoparticles, mesoporous silica to get organic-inorganic hybrids, which have interesting potential for bio-applications
Biography
Lei Tao, born in 1976, graduated from University of Science and Technology of China to get his Bachelor and Master degrees in 1999 and 2002, respectively. After his Ph.D. study in Warwick University (2003-2006), he moved to University of California, Los Angeles (UCLA, USA) in 2006, and then University of New Southwales (UNSW, Australia) in 2008 as a postdoctoral research assistant. In 2010, he joined Department of Chemistry, Tsinghua University. His research interests are focused on the synthesis of well-defined polymers and applications of those polymers in biological areas. He has published more than 50 SCI papers, and the H-index is 23 by now
Top