alexa Chromatin And The Three-dimensional Organization Of The Human Genome
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference on Genomics & Pharmacogenomics
September 08-10, 2014 DoubleTree by Hilton Hotel Raleigh-Brownstone-University, USA

Istvan Ladunga
Accepted Abstracts: J Mol Genet Med
DOI: 10.4172/1747-0862.S1.004
Abstract
We present specific complexes of transcription factors and histone remodeling enzymes that are highly correlated with the formation of intrachromosomal DNA loops in the human genome. These DNA-loops bring proximal promoter regions into physical contact with distal enhancers, connect co-expressed genes and genes of locus control regions, and responsible for the three-dimensional organization of the cellular nucleus. Our results are based on published recent high-resolution methods of Chromosomal Conformation Capture (HiC, 5C) have revealed tens of thousands of DNA loops within the human chromosomes. We also used ~45 million binding sites of transcriptional regulators and polymerases based on the chromatin immunoprecipitation experiments of the Encyclopedia of DNA Elements Project. We found statistically highly significant and reproducible enrichment of CCCAT-binding factor (CTCF), double-strand break repair protein RAD21, zinc-finger DNA binding protein ZNF143, Yin-Yang 1, and several others. We found that several interconnected DNA-loops bring highly co-regulated genes into 3D proximity despite large distances in sequence. A detailed analysis of the alpha-globin cluster is presented in both pluripotent embryonic stem cells and lung fibroblasts in human and to some extent, in murine cells. In general terms, we present a correspondence between to co-regulation network of the human genome, the patterns of chromatin modifications, the binding sites of the transcriptional regulators, and the three-dimensional architecture of the chromosomes.
Biography
Istvan Ladunga completed his PhD at the Budapest University of Sciences. He served at the Institute of Computer Science and Automation of the Hungarian Academy of Sciences, the Natl. Committee for Technological Development, Hungary, the Dept. Mathematics, Stanford University, the Dept. Human Genetics, Baylor College of Medicine, SmithKline Beecham Pharmaceuticals, and Celera Genomics. He has published 134 patents and copyrights, 35 papers, and a book.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords