Reach Us +44-1202068036
Chromosomal Instability, Inflammation, Plasmacytic Neoplasms, Elevated Stem Cell Antigen 1 Expression In Mice Deficient In Rrm2b Gene | 19919
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Hematology & Blood Disorders

Lufen Chang
Accepted Abstracts: J Blood Disorders Transf
DOI: 10.4172/2155-9864.S1.008
Chronic inflammation has a tight cause-and-effect relationship with DNA damage by inflicting tissue damage and increasing cancer risk. Stem-cell recruitment by chronic inflammation to injury sites may potentiate tumorigenesis. Rrm2b , a key enzyme in de novo deoxyribonucleotide synthesis, is involved in DNA damage repair. Rrm2b gene loss leads to severe numerical and structural chromosome abnormalities that cause ATM activation, inducing p-Ser85 IKK γ NEMO and I κ B kinase (IKK). NF-kB consequently induced by IKK triggered sustained IL-6 expression that constitutively activates STAT3 in Rrm2b -deficient cells. Rrm2b-/- mice developed dysfunctional immunologic and hematopoietic systems (high serum IL-6, splenic hemorrhage, abnormal IgM and IgG levels, lymphocytosis, neutrophilia, and thrombocytosis). 30-40% of aged Rrm2b heterozygous knockout mice developed plasma cell neoplasms and suffered from progressive splenomegaly and ascites. The genetic ablation of IL-6 suppressed STAT3 induction and delayed hematologic disorders and mortality from renal failure in Rrm2b-/- mice. Rrm2b protein levels were found inversely correlated with IL-6 expression in bone marrows of multiple myeloma patients. Stem Cell Antigen 1 positive (SCA-1+) small stem cell populations (≤6 μ m in diameter) which are termed spore-like cells, blastomere-like stem cells (BLSCs), or very-small embryonic-like stem cells (VSELs), Blastomere-like stem cells (BLSCs) accumulated more than 4 folds in Rrm2b-/- than Rrm2b +/+ bone marrows. The functional mechanisms underlying SCA-1+ BLSCs in Rrm2b-/- bone marrows for tissue repairing and tumorigenesis are currently investigated.
Lufen Chang obtained her PhD from Department of Cell biology of Vanderbilt University in Nashville, Tennessee, and Postdoctoral studies with Dr. Michael Karinin Department of Pharmacology from University of California, San Diego. She is currently an Assistant Research Professor in Department of Molecular Pharmacology and a member of Comprehensive Cancer Center in City of Hope. She has published numerous papers in high impact journals including, Nature, Cell, Cell Reports, PNAS, JCO, and Immunity.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version