alexa Circulating Level Of Interleukin (IL)-18 In Helicobacter Pylori-infected Patients, And Its Associations With Bacterial CagA And VacA Virulence Factors
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th International Conference on Vaccines & Vaccination
September 24-26, 2014 Valencia Convention Centre, Spain

Ebrahim Eskandari-Nasab
Accepted Abstracts: J Vaccines Vaccin
DOI: 10.4172/2157-7560.S1.022
Abstract
Background: We analyzed the impact of Interleukin (IL)-18 promoter polymorphisms on IL-18 serum levels in H. pylori- infected duodenal ulcer (DU) patients and healthy asymptomatic (AS) carriers. We also aimed to determine the association of the H. pylori virulence factors, CagA and VacA antibodies with serum concentrations of IL-18 as to elucidate any correlation between them. Methods: Three groups including DU patients (67 individuals), AS carriers (48 individuals), and H. pylori-negative subjects (26 individuals) were enrolled. Serum concentrations of IL-18 were determined by ELISA. Patient sera were tested by Western blot method to determine the presence of serum antibodies to bacterial CagA, VacA. Genotyping of IL-18 promoter polymorphisms at positions -137 G/C and -607 C/A were performed by Allele-Specific Primer PCR protocol. Results: Our study revealed that serum IL-18 levels are positively influenced by CagA-positive H. pylori strains, so that maximum levels of IL-18 were detected in DU patients with the CagA+ phenotype, regardless of the presence of the anti- VacA antibody. Regarding IL-18 promoter polymorphisms, the AA genotype and A allele at position −607 C/A found to be significantly lower in DU patients than in AS carriers and H. pylori-negative subjects (P=0.032 and 0.043, respectively). Conclusions: IL-18 -607 C variant was associated with higher levels of serum IL-18 and increased risk of DU. Moreover, our findings indicated that serum concentrations of IL-18 were influenced by CagA factor, irrespective of the VacA status, suggesting that high levels of IL-18 in CagA positive subjects are predisposed to susceptibility to DU.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords