Journal of Clinical Toxicology
Open Access

Clonidine as an adjuvant in the management of acute poisoning by anticholinesterase pesticides

6^th Global Summit on Toxicology & Applied Pharmacology

October 17-19, 2016 Houston, USA

Amira Amin Wahdan, El-Ebiary A A, Gad S A and El-Mehallawi I H

Tanta University, Egypt

Posters & Accepted Abstracts: J Clinic Toxicol

Abstract :

Anticholinesterase pesticides are widely used in agriculture and domestic settings throughout the world, and they are responsible for great morbidity and mortality. In Egypt and other developing countries, there is a pressing need for new affordable antidotes to treat anticholinesterase pesticide poisoning. Hence, this study was conducted to evaluate the safety and effectiveness of moderate doses of clonidine in the management of adult patients with acute anticholinesterase pesticide poisoning. This study was an open-label, phase II pilot clinical trial. Sixty patients with acute anticholinesterase pesticide poisoning gave consent to participate in the study. They were divided into 2 equal groups, with 30 patients in each group. Group I received clonidine plus the routine treatment, while group II received only the routine treatment. Patients were subjected to full history taking, and their vital and clinical data were recorded. Serum cholinesterase levels and routine laboratory investigations were measured. The different outcomes of the patients were assessed. The baseline characteristics of both groups were similar. Thirteen (43.3%) patients developed significant hypotension during clonidine treatment. The clinical outcomes (including mortality, need for assisted ventilation, length of hospital stay, and total doses of atropine) showed no significant differences between the two groups. The use of clonidine in acute anticholinesterase pesticide poisoning may be associated with a high incidence of hypotension requiring intervention. The clinical outcomes may not significantly improve in clonidine-treated patients.

Biography :

Amira Amin Wahdan has completed her MD degree from Tanta University. She is a Lecturer in Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Tanta University. She is a reviewer in reputed journal.

Email: dr.awahdan@yahoo.com