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ossible synergistic effects of co-administration of chloramphenicol and multivitamin haematinic complex via free radical
generation were investigated using biomarkers of oxidative stress. Lipid peroxidation and hydrogen peroxide was assessed.
The levels of non-enzymatic antioxidants (reduced glutathione (GSH) and enzymatic antioxidants (superoxide dismutase (SOD),
catalase (CAT), glutathione-S-transferase (GST), the activities of gamma glutamyl transferase (GT) and glucose-6-phosphatase
were also assessed 10 days post administration. Tissues from the kidney were sectioned for necropsy. Oral administration of
Chloramphenicol (28 mg/kg body weight) and multivitamin haematinic complex (5ml /kg body weight) for 10 days induced
significant increase in lipid peroxidation indices and hydrogen peroxide in rats. The level of GSH and the activities of SOD, CAT,
and GST were also significantly increased in the treated rats. Also, the activity of GT and glucose-6-phosphatase was significantly
reduced in animals treated with chloramphenicol plus multivitamin haematinic complex and multivitamin haematinic complex
alone. However, there was significant increase in oxidative stress in rats treated with combination of Chloramphenicol and
multivitamin haematinic complex compared with either chloramphenicol or multivitamin haematinic complex treated group.
Necropsy revealed severe generalized tubular necrosis, cellular infiltration and presence of protein casts in tubular lumen of
treated rats. Together, the effect of Chloramphenicol on enzymatic and non- enzymatic antioxidants components is related to
the action of chloramphenicol presumably, via free radical mechanism and that co administration of Chloramphenicol with
multivitamin haematinic complex can potentiate its toxic action
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