Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Mohammed Saied Mohammed Bakeer
Al-Azhar University, Egypt
Posters & Accepted Abstracts: J Clin Exp Cardiolog
The initial ��?waterfall� or ��?cascade� model for coagulation was proposed in 1964 by MacFarlane, Davie and Ratnoff. Obscure in this model, is the role of the contact (intrinsic) pathway. As the known stimulus for it, has been largely non-physiological such as glass and kaolin. Also people with deficiency of factor XII show no significant bleeding tendencies. While the connection between coagulation, inflammation and thrombosis is well known observation, however its exact mechanism was not clear. In recent years there has been a growing body of literature supporting the role of negatively charged, poly anionic linear polymers such as polyphosphate (poly-P) and extracellular nucleic acids (RNA and DNA) in thrombosis and inflammation. Poly-P is a highly anionic, linear polymer of orthophosphate, which is stored as metachromatic granules in many cells. The recent discovery that the dense granules of the platelets are actually storage of (Poly- P) and the observation that (Poly- P) can strongly stimulate contact pathway has opened a way for a new understanding of coagulation system. Activation of the contact system by long-chain (poly-p) can also be strongly pro-inflammatory, in a manner dependent on factor XII activation and release of bradykinin from high molecular weight kininogen. It was also noted that platelet (poly-p) causes an approximately 3000-fold increase in the rate of back-activation of factor XI by thrombin, enhances the rate of factor V activation to Va by factor XIa. While (poly-p) is released mainly from platelets, extracellular DNA and RNA are released mainly from neutrophils; neutrophil extracellular traps (NETs). Both (poly-p) and (NETs) almost have the same function.
Email: dr.Mohammed.bakeer@gmail.com