alexa Combinative Drug Therapy For Cancer Treatment: Exploring Synergistic Mode Of Action Of Amino And Carboxy Terminal Domain Inhibitors Of Heat Shock Protein 90 (HSP90)
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

14th World Cancer & Anti-Cancer Therapy Convention
November 21-23, 2016 Dubai, UAE

Bhaskar Kr Chatterjee
Indian Institute of Technology, Delhi, India
Posters & Accepted Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956.C1.094
Abstract
This work entails the characterization of how inhibitors work against the various properties of Hsp90, a eukaryotic chaperone. For decades, drugs have been designed against this molecule, as it has over 200 client proteins that include kinases and steroidhormone receptors. Many of them have been implicated in several types of cancer, in their mutated versions. Proper folding enables mutant proteins to become functional and develop cancer in tissues. Inhibiting one or more chaperone functions will reduce amount of functional mutants. This work studies in detail how commercially used (geldanamycin and novobiocin) as well as novel inhibitors (KU compounds) affect the chaperone properties of Hsp90 viz., ATPase activity and prevention of aggregation of denatured substrates. It also investigates the effect of these inhibitors in the refolding of luciferase (model substrate) inside HeLa cells, which are given heat shock to denature luciferase. It also tries to correlate the in vitro data by using in silico models of Hsp90 bound to these inhibitors, and exploring the global and local changes that occur in MD simulations. Most importantly, it explores if two different classes of inhibitors (for example, geldanamycin & novobiocin) can act synergistically, to enhance inhibition, as compared to the inhibition of an individual drug. This can be thought of as a lab scale project to aim for a novel drug therapy for cancer treatment, as results are indicating synergistic mode of action in some of the in vitro assays.
Biography

Bhaskar Kr Chatterjee is currently pursuing PhD from IIT-Delhi. He is a fifth year student, working on mechanistic action of Hsp90 inhibitors both in vitro and in cancer cell lines. He is also involved in in silico studies to correlate his in vitro work, in collaboration with Super-Computing Facility, IIT-D. He aims to carry out animal model studies to actually understand whether synergistic mode of action is helpful in partially/fully abrogating cancerous lesions, with minimal side-effects.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords