Reach Us +44-1477412632
Combined Effect Of Syzygium Cumini Seed Extract With Acarbose Ameliorates Glucose Intolerance And Oxidative Stress In High Fat Diet Induced Obesity | 6166
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Combined effect of Syzygium Cumini seed extract with Acarbose ameliorates glucose intolerance and oxidative stress in high fat diet induced obesity

3rd World Congress on Diabetes & Metabolism

Shakti Singh and N. Prem Kumar

Posters: J Diabetes Metab

DOI: 10.4172/2155-6156.S1.019

Obesity plays a vitalrole in the insulin resistance syndrome, which includes hyperinsulinemia and type 2 diabetes mellitus. The aim of the present investigation was to evaluate theeffect of Syzygium cuminiseed kernel extract (SSKE) in combination with acarbose in high fat diet fed induced obese rats. OGTT, single and multiple dose study was carried out. Rats were divided into different groups. Group I fed with normal pellet diet and group II was fed with high fat diet (HFD), considered as diabetic control. Groups III to V were fed with HFD plus SSKE, HFD plus acarbose and HFD plus SSKE and acarbose respectively. Treatment schedule started along with the diet for 10 weeks. Anti-oxidative enzymes and histopathology of the pancreas was carried out. Number of beta cell in the islets was also evaluated. OGTT was also performed at the end of the treatment period. Body weight was recorded throughout the treatment period. Diabetic rats showed decrease in antioxidant enzymes and raise in glucose intolerance when compared with normal control. The combined therapy of SSKE and acarbose significantly restored the antioxidant enzymes towards normal. Impaired glucose tolerance in this group was brought back to normal. Histopathological studies showed the presence of increase in beta cell in islets of pancreas. All the above results suggest that treatment with the combination of SSKE and acarbose might be useful in preventing the development of type 2 diabetes mellitus.
Shakti Singh, research scholar has completed his Bpharmacy from from Amar Saheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy and Mpharmacy from Krupanidhi College of Pharmacy. Has participated in Participated in poster presentation on Antinociceptive effect of Terminalia Bellirica Fruit extract in Diabetic Neuropathic Pain in Rats in IPSCON 2011. Attended workshop on ?Role of Intellectual Property Rights in Pharmaceutical Industry? in association with IIPTA on 30th& 31st March 2012.