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Obesity plays a vitalrole in the insulin resistance syndrome, which includes hyperinsulinemia and type 2 diabetes mellitus.
The aim of the present investigation was to evaluate theeffect of Syzygium cuminiseed kernel extract (SSKE) in combination
with acarbose in high fat diet fed induced obese rats. OGTT, single and multiple dose study was carried out. Rats were divided
into different groups. Group I fed with normal pellet diet and group II was fed with high fat diet (HFD), considered as diabetic
control. Groups III to V were fed with HFD plus SSKE, HFD plus acarbose and HFD plus SSKE and acarbose respectively.
Treatment schedule started along with the diet for 10 weeks. Anti-oxidative enzymes and histopathology of the pancreas was
carried out. Number of beta cell in the islets was also evaluated. OGTT was also performed at the end of the treatment period.
Body weight was recorded throughout the treatment period. Diabetic rats showed decrease in antioxidant enzymes and raise in
glucose intolerance when compared with normal control. The combined therapy of SSKE and acarbose significantly restored the
antioxidant enzymes towards normal. Impaired glucose tolerance in this group was brought back to normal. Histopathological
studies showed the presence of increase in beta cell in islets of pancreas. All the above results suggest that treatment with the
combination of SSKE and acarbose might be useful in preventing the development of type 2 diabetes mellitus.
Shakti Singh, research scholar has completed his Bpharmacy from from Amar Saheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy
and Mpharmacy from Krupanidhi College of Pharmacy. Has participated in Participated in poster presentation on Antinociceptive effect of Terminalia
Bellirica Fruit extract in Diabetic Neuropathic Pain in Rats in IPSCON 2011. Attended workshop on ?Role of Intellectual Property Rights in
Pharmaceutical Industry? in association with IIPTA on 30th& 31st March 2012.
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