alexa Combined Therapies For Spinal Cord Injury Repair
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th World Congress on Cell Science & Stem Cell Research
June 24-26, 2014 Valencia Conference Centre, Valencia, Spain

Pavla Jendelov?
Accepted Abstracts: J Cell Sci Ther
DOI: 10.4172/2157-7013.S1.030
Abstract
T remendous efforts have been made to improve locomotor function after spinal cord injury (SCI) by searching for the proper therapy. We compared the effects of implanted olfactory ensheathing cells (OEG) and/or mesenchymal stem cells (MSCs) into SCI with the implantation of neural precursors (NPs) derived from either fetal spinal tissue or induced pluripotent cells. All cells regardless of their origin spared the white matter and improved functional outcome. NPs robustly survived in the lesion cavity and expressed neurotrophins; 4 months post-implantation some of the cells matured into Islet2+ and Chat+ cells. All transplanted cells reduced inflammatory cytokines, such as MIP1α and TNFα. Another therapeutic goal is treating SCI by a combination of stem cells with bridging biomaterials. Hydrogels seeded with MSCs or NPs were implanted into SCI, and cell survival and tissue reconstruction were evaluated. The hydrogels adhered well to the surrounding tissue and completely filled the post-traumatic cavity. Cells survived in the hydrogel, and neurofilaments, blood vessels and Schwann cells infiltrated the implant. Combined therapy also prevented tissue atrophy and reduced scar formation. Our results demonstrate that the transplantation of neurogenic as well as non-neurogenic stem cells into SCI improves functional outcome by providing trophic support to the spared axons in the injured tissue. Neurogenic stem cells have the ability to interact with the host tissue and differentiate into a more mature phenotype, such as motor neurons. Treatment of chronic spinal cord injury will require a combination of cell therapy and lesion bridging
Biography
Pavla Jendelova is the Head of the Laboratory of Tissue Culture and Stem Cells in the Institute of Experimental Medicine ASCR in Prague, Czech Republic. Her scientific interests are cell and combined therapies for spinal cord injury treatment, the development of new bio-modified scaffolds based on polymeric hydrogels as carriers for cell therapy and the development of nanoparticles for cell imaging. She is the author or co-author of 65 original publications in impacted journals and the holder of three biotechnology patents. Her publications have been cited more than 1600 times, and her h-index is 23.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

nutrition[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords